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Inability to effectively suppress anticipated irrelevant information in healthy older adults.
Clapp, W.C., Litke, R., Murthy, N., Gazzaley, A.Cognitive Neuroscience Meeting (2008) 

Previously we showed that when relevant and irrelevant information were presented quickly and randomly to older adults, they have a deficit in suppressing irrelevant information. The present experiment tested the ability of older adults to suppress anticipated irrelevant information.  EEG was recorded from 16 healthy older subjects (age: 60-82) as they participated in a single face delayed-recognition task, comprised of four conditions; No Distractor, Ignore-Distractor (ID), Attend-Distractor (AD), and Passive View. In the distractor conditions, the degree to which one must attend to distracting information (a face in the delay period) was manipulated.  In the ID condition, subjects were cued to anticipate the irrelevant distractor, while in the AD condition they were directed to attend to the distractor (i.e. make a simple decision about it).
  Behaviorally, subjects’ working memory performance declined in the presence of distraction. Recently, we found that young subjects participating in the same experiment exhibited a N170 latency earliest for relevant stimuli (attended distractors), followed by passive view, and latest for irrelevant stimuli (ignored distractors).  In older subjects, the N170 peaks earliest for attended stimuli, but responses to irrelevant stimuli peak at a similar latency as passively viewed stimuli, suggesting a selective inability to suppress irrelevant information even when the distractor could be anticipated.  Supportive behavioral evidence of an inability to suppress distractors was obtained. Similar to younger subjects, this neural measure of suppression correlated with working memory accuracy, revealing that older subjects that exhibit N170 latency suppression of irrelevant information perform better at the task.

 
 

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